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Structure paper

TitleStructural characterization of monoclonal antibodies targeting C-terminal Ser404region of phosphorylated tau protein.
Journal, issue, pagesMAbs, Vol. 11, Page 477-488, Year 2019
Publish dateMay 4, 2018 (structure data deposition date)
AuthorsChukwu, J.E. / Congdon, E.E. / Sigurdsson, E.M. / Kong, X.P.
External linksMAbs / PubMed:30794086
MethodsX-ray diffraction
Resolution1.799 - 2.999 Å
Structure data

PDB-6dc7:
Apo Fab structure of mouse monoclonal antibody 8B2
Method: X-RAY DIFFRACTION / Resolution: 1.901 Å

PDB-6dc8:
Fab/epitope complex of mouse monoclonal antibody 8B2 targeting a non-phosphorylated tau epitope.
Method: X-RAY DIFFRACTION / Resolution: 1.799 Å

PDB-6dc9:
Fab/epitope complex of human chimeric monoclonal antibody h4E6 targeting a phosphorylated tau epitope.
Method: X-RAY DIFFRACTION / Resolution: 2.999 Å

PDB-6dca:
Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope.
Method: X-RAY DIFFRACTION / Resolution: 2.599 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-PO4:
PHOSPHATE ION

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / monoclonal antibody / fab / tau / phosphorylation state -specific antibody / phosphorylation state-specific antibody

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