| タイトル | The evolution of multiple active site configurations in a designed enzyme. |
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| ジャーナル・号・ページ | Nat Commun, Vol. 9, Page 3900-3900, Year 2018 |
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| 掲載日 | 2018年1月22日 (構造データの登録日) |
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著者 | Hong, N.S. / Petrovic, D. / Lee, R. / Gryn'ova, G. / Purg, M. / Saunders, J. / Bauer, P. / Carr, P.D. / Lin, C.Y. / Mabbitt, P.D. ...Hong, N.S. / Petrovic, D. / Lee, R. / Gryn'ova, G. / Purg, M. / Saunders, J. / Bauer, P. / Carr, P.D. / Lin, C.Y. / Mabbitt, P.D. / Zhang, W. / Altamore, T. / Easton, C. / Coote, M.L. / Kamerlin, S.C.L. / Jackson, C.J. |
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リンク | Nat Commun / PubMed:30254369 |
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| 手法 | X線回折 |
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| 解像度 | 1.45 - 2.68 Å |
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| 構造データ | PDB-6c7h: Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 18 Design Trp50Ala mutant 手法: X-RAY DIFFRACTION / 解像度: 2.43 Å PDB-6c7m: Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 19 round 5 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-6c7t: Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 20 round 5 手法: X-RAY DIFFRACTION / 解像度: 1.83 Å PDB-6c7v: Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 22 round 5 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å PDB-6c8b: Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 23 round 6 手法: X-RAY DIFFRACTION / 解像度: 1.61 Å PDB-6cai: Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 24 round 7 手法: X-RAY DIFFRACTION / 解像度: 1.82 Å PDB-6ct3: Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 27 round 7-2 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6dc1: Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 25 round 7 手法: X-RAY DIFFRACTION / 解像度: 2.68 Å PDB-6dkv: Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 21 round 5 手法: X-RAY DIFFRACTION / 解像度: 1.89 Å PDB-6dnj: Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 28 round 5 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å |
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| 化合物 | ChemComp-TRS: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH緩衝剤*YM
ChemComp-B3P: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH緩衝剤*YM
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| 由来 | - synthetic construct (人工物)
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キーワード | LYASE / Kemp Eliminase / Directed Evolution / KE07 / DE NOVO PROTEIN |
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