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| Title | Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 61, Page 8597-8612, Year 2018 |
| Publish date | May 3, 2018 (structure data deposition date) |
 Authors | Fensome, A. / Ambler, C.M. / Arnold, E. / Banker, M.E. / Brown, M.F. / Chrencik, J. / Clark, J.D. / Dowty, M.E. / Efremov, I.V. / Flick, A. ...Fensome, A. / Ambler, C.M. / Arnold, E. / Banker, M.E. / Brown, M.F. / Chrencik, J. / Clark, J.D. / Dowty, M.E. / Efremov, I.V. / Flick, A. / Gerstenberger, B.S. / Gopalsamy, A. / Hayward, M.M. / Hegen, M. / Hollingshead, B.D. / Jussif, J. / Knafels, J.D. / Limburg, D.C. / Lin, D. / Lin, T.H. / Pierce, B.S. / Saiah, E. / Sharma, R. / Symanowicz, P.T. / Telliez, J.B. / Trujillo, J.I. / Vajdos, F.F. / Vincent, F. / Wan, Z.K. / Xing, L. / Yang, X. / Zhang, L. |
 External links | J. Med. Chem. / PubMed:30113844 |
| Methods | X-ray diffraction |
| Resolution | 2 - 2.48 Å |
| Structure data |  PDB-6dbk:  PDB-6dbm:  PDB-6dbn: |
| Chemicals |  ChemComp-G5D:  ChemComp-HOH:  ChemComp-G4J: |
| Source |
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 Keywords | TRANSFERASE / kinase |
homo sapiens (human)