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TitleChemical genetic inhibition of DEAD-box proteins using covalent complementarity.
Journal, issue, pagesNucleic Acids Res., Vol. 46, Page 8689-8699, Year 2018
Publish dateApr 8, 2018 (structure data deposition date)
AuthorsBarkovich, K.J. / Moore, M.K. / Hu, Q. / Shokat, K.M.
External linksNucleic Acids Res. / PubMed:30102385
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-6cz5:
Crystal structure of small molecule AMP-acrylamide covalently bound to DDX3 S228C
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-FPJ:
5'-O-[(R)-hydroxy(propanoylamino)phosphoryl]adenosine

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / Inhibitor / DEAD-box protein / HYDROLASE-HYDROLASE INHIBITOR complex

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