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Structure paper

TitleSmall molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
Journal, issue, pagesPLoS ONE, Vol. 13, Page e0198374-e0198374, Year 2018
Publish dateApr 7, 2018 (structure data deposition date)
AuthorsQiu, L. / Levine, K. / Gajiwala, K.S. / Cronin, C.N. / Nagata, A. / Johnson, E. / Kraus, M. / Tatlock, J. / Kania, R. / Foley, T. / Sun, S.
External linksPLoS ONE / PubMed:29879184
MethodsX-ray diffraction
Resolution1.5 - 2.5 Å
Structure data

PDB-6cz2:
Structure of the PTK6 kinase domain
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6cz3:
Structure of the PTK6 kinase domain bound to a type I inhibitor (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-6cz4:
Structure of the PTK6 kinase domain bound to a type II inhibitor 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-FLJ:
(3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone

ChemComp-ACT:
ACETATE ION

ChemComp-K:
Unknown entry

ChemComp-FKY:
2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Protein kinase / PTK6 / Transferase/Transferase Inhibitor / Transferase-Transferase Inhibitor complex

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