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Structure paper

TitleStructural Plasticity of Neurexin 1α: Implications for its Role as Synaptic Organizer.
Journal, issue, pagesJ Mol Biol, Vol. 430, Issue 21, Page 4325-4343, Year 2018
Publish dateOct 19, 2018
AuthorsJianfang Liu / Anurag Misra / M V V V Sekhar Reddy / Mark Andrew White / Gang Ren / Gabby Rudenko /
PubMed Abstractα-Neurexins are synaptic organizing molecules implicated in neuropsychiatric disorders. They bind and arrange an array of different partners in the synaptic cleft. The extracellular region of ...α-Neurexins are synaptic organizing molecules implicated in neuropsychiatric disorders. They bind and arrange an array of different partners in the synaptic cleft. The extracellular region of neurexin 1α (n1α) contains six LNS domains (L1-L6) interspersed by three Egf-like repeats. N1α must encode highly evolved structure-function relationships in order to fit into the narrow confines of the synaptic cleft, and also recruit its large, membrane-bound partners. Internal molecular flexibility could provide a solution; however, it is challenging to delineate because currently no structural methods permit high-resolution structure determination of large, flexible, multi-domain protein molecules. To investigate the structural plasticity of n1α, in particular the conformation of domains that carry validated binding sites for different protein partners, we used a panel of structural techniques. Individual particle electron tomography revealed that the N-terminally and C-terminally tethered domains, L1 and L6, have a surprisingly limited range of conformational freedom with respect to the linear central core containing L2 through L5. A 2.8-Å crystal structure revealed an unexpected arrangement of the L2 and L3 domains. Small-angle X-ray scattering and electron tomography indicated that incorporation of the alternative splice insert SS6 relieves the restricted conformational freedom between L5 and L6, suggesting that SS6 may work as a molecular toggle. The architecture of n1α thus encodes a combination of rigid and flexibly tethered domains that are uniquely poised to work together to promote its organizing function in the synaptic cleft, and may permit allosterically regulated and/or concerted protein partner binding.
External linksJ Mol Biol / PubMed:30193986 / PubMed Central
MethodsEM (tomography) / X-ray diffraction
Resolution2.84 - 16.5 Å
Structure data

EMDB-7639:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.08 Å

EMDB-7640:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.28 Å

EMDB-7641:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.5 Å

EMDB-7642:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.44 Å

EMDB-7643:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.74 Å

EMDB-7644:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 16.0 Å

EMDB-7645:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 16.27 Å

EMDB-7646:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.57 Å

EMDB-7647:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.55 Å

EMDB-7648:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 16.06 Å

EMDB-7649:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.74 Å

EMDB-7650:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.52 Å

EMDB-7651:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.58 Å

EMDB-7652:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.93 Å

EMDB-7653:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.11 Å

EMDB-7654:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.82 Å

EMDB-7655:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.72 Å

EMDB-7656:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.06 Å

EMDB-7657:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 15.22 Å

EMDB-7658:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 16.08 Å

EMDB-7659:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 021)
Method: EM (tomography) / Resolution: 15.96 Å

EMDB-7660:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 002)
Method: EM (tomography) / Resolution: 15.28 Å

EMDB-7661:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 003)
Method: EM (tomography) / Resolution: 15.5 Å

EMDB-7662:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 004)
Method: EM (tomography) / Resolution: 15.44 Å

EMDB-7663:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 005)
Method: EM (tomography) / Resolution: 15.74 Å

EMDB-7664:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 006)
Method: EM (tomography) / Resolution: 16.0 Å

EMDB-7665:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 007)
Method: EM (tomography) / Resolution: 16.27 Å

EMDB-7666:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 008)
Method: EM (tomography) / Resolution: 15.57 Å

EMDB-7667:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 009)
Method: EM (tomography) / Resolution: 15.55 Å

EMDB-7668:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 010)
Method: EM (tomography) / Resolution: 16.06 Å

EMDB-7669:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 011)
Method: EM (tomography) / Resolution: 15.74 Å

EMDB-7670:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 012)
Method: EM (tomography) / Resolution: 15.52 Å

EMDB-7671:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 013)
Method: EM (tomography) / Resolution: 15.28 Å

EMDB-7672:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 014)
Method: EM (tomography) / Resolution: 15.93 Å

EMDB-7673:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 015)
Method: EM (tomography) / Resolution: 15.11 Å

EMDB-7674:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 016)
Method: EM (tomography) / Resolution: 15.82 Å

EMDB-7675:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 017)
Method: EM (tomography) / Resolution: 15.72 Å

EMDB-7676:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 018)
Method: EM (tomography) / Resolution: 15.06 Å

EMDB-7677:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 019)
Method: EM (tomography) / Resolution: 15.22 Å

EMDB-7678:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 020)
Method: EM (tomography) / Resolution: 16.08 Å

EMDB-7679:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 022)
Method: EM (tomography) / Resolution: 14.75 Å

EMDB-7680:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 023)
Method: EM (tomography) / Resolution: 14.6 Å

EMDB-7681:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 024)
Method: EM (tomography) / Resolution: 15.5 Å

EMDB-7682:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 025)
Method: EM (tomography) / Resolution: 14.7 Å

EMDB-7683:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 026)
Method: EM (tomography) / Resolution: 14.92 Å

EMDB-7684:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 027)
Method: EM (tomography) / Resolution: 14.99 Å

EMDB-7685:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 028)
Method: EM (tomography) / Resolution: 15.77 Å

EMDB-7686:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 029)
Method: EM (tomography) / Resolution: 15.13 Å

EMDB-7687:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 030)
Method: EM (tomography) / Resolution: 14.95 Å

EMDB-7688:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 031)
Method: EM (tomography) / Resolution: 16.14 Å

EMDB-7689:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 032)
Method: EM (tomography) / Resolution: 14.92 Å

EMDB-7690:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 033)
Method: EM (tomography) / Resolution: 14.94 Å

EMDB-7691:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 034)
Method: EM (tomography) / Resolution: 15.53 Å

EMDB-7692:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 035)
Method: EM (tomography) / Resolution: 15.95 Å

EMDB-7693:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 036)
Method: EM (tomography) / Resolution: 15.6 Å

EMDB-7694:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 037)
Method: EM (tomography) / Resolution: 15.88 Å

EMDB-7695:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 038)
Method: EM (tomography) / Resolution: 15.09 Å

EMDB-7696:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 039)
Method: EM (tomography) / Resolution: 15.43 Å

EMDB-7697:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 040)
Method: EM (tomography) / Resolution: 14.95 Å

EMDB-7698:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 041)
Method: EM (tomography) / Resolution: 14.79 Å

EMDB-7699:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 042)
Method: EM (tomography) / Resolution: 16.05 Å

EMDB-7700:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 043)
Method: EM (tomography) / Resolution: 14.94 Å

EMDB-7701:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 044)
Method: EM (tomography) / Resolution: 15.84 Å

EMDB-7702:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 045)
Method: EM (tomography) / Resolution: 14.98 Å

EMDB-7703:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 046)
Method: EM (tomography) / Resolution: 15.48 Å

EMDB-7704:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 047)
Method: EM (tomography) / Resolution: 15.03 Å

EMDB-7705:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 048)
Method: EM (tomography) / Resolution: 15.4 Å

EMDB-7706:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 049)
Method: EM (tomography) / Resolution: 14.95 Å

EMDB-7707:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 050)
Method: EM (tomography) / Resolution: 15.08 Å

EMDB-7708:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 051)
Method: EM (tomography) / Resolution: 15.6 Å

EMDB-7709:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 052)
Method: EM (tomography) / Resolution: 15.12 Å

EMDB-7710:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 053)
Method: EM (tomography) / Resolution: 16.04 Å

EMDB-7711:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 054)
Method: EM (tomography) / Resolution: 15.69 Å

EMDB-7712:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 055)
Method: EM (tomography) / Resolution: 14.84 Å

EMDB-7713:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 056)
Method: EM (tomography) / Resolution: 14.86 Å

EMDB-7714:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 057)
Method: EM (tomography) / Resolution: 14.86 Å

EMDB-7715:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 058)
Method: EM (tomography) / Resolution: 15.04 Å

EMDB-7716:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 059)
Method: EM (tomography) / Resolution: 16.09 Å

EMDB-7717:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 060)
Method: EM (tomography) / Resolution: 15.26 Å

EMDB-7718:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 061)
Method: EM (tomography) / Resolution: 15.01 Å

EMDB-7719:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 062)
Method: EM (tomography) / Resolution: 15.39 Å

EMDB-7720:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 001)
Method: EM (tomography) / Resolution: 14.8 Å

EMDB-7721:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 064)
Method: EM (tomography) / Resolution: 14.7 Å

EMDB-7722:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 063)
Method: EM (tomography) / Resolution: 14.8 Å

EMDB-7723:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 065)
Method: EM (tomography) / Resolution: 15.1 Å

EMDB-7724:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 066)
Method: EM (tomography) / Resolution: 14.9 Å

EMDB-7725:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 067)
Method: EM (tomography) / Resolution: 15.6 Å

EMDB-7726:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 068)
Method: EM (tomography) / Resolution: 14.8 Å

EMDB-7727:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 069)
Method: EM (tomography) / Resolution: 16.2 Å

EMDB-7728:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 070)
Method: EM (tomography) / Resolution: 16.2 Å

EMDB-7729:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 071)
Method: EM (tomography) / Resolution: 14.4 Å

EMDB-7730:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 072)
Method: EM (tomography) / Resolution: 15.1 Å

EMDB-7731:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 073)
Method: EM (tomography) / Resolution: 15.8 Å

EMDB-7732:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 074)
Method: EM (tomography) / Resolution: 14.8 Å

EMDB-7733:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 075)
Method: EM (tomography) / Resolution: 14.9 Å

EMDB-7734:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 076)
Method: EM (tomography) / Resolution: 15.5 Å

EMDB-7735:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 077)
Method: EM (tomography) / Resolution: 15.5 Å

EMDB-7736:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 078)
Method: EM (tomography) / Resolution: 15.0 Å

EMDB-7737:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 079)
Method: EM (tomography) / Resolution: 14.9 Å

EMDB-7738:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 080)
Method: EM (tomography) / Resolution: 15.2 Å

EMDB-7739:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 081)
Method: EM (tomography) / Resolution: 15.9 Å

EMDB-7740:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 082)
Method: EM (tomography) / Resolution: 15.6 Å

EMDB-7741:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 083)
Method: EM (tomography) / Resolution: 15.3 Å

EMDB-7742:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 084)
Method: EM (tomography) / Resolution: 14.8 Å

EMDB-7743:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 085)
Method: EM (tomography) / Resolution: 15.8 Å

EMDB-7744:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 086)
Method: EM (tomography) / Resolution: 14.9 Å

EMDB-7745:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 087)
Method: EM (tomography) / Resolution: 14.8 Å

EMDB-7746:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 088)
Method: EM (tomography) / Resolution: 15.08 Å

EMDB-7747:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 089)
Method: EM (tomography) / Resolution: 15.9 Å

EMDB-7748:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 090)
Method: EM (tomography) / Resolution: 15.3 Å

EMDB-7749:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 091)
Method: EM (tomography) / Resolution: 15.6 Å

EMDB-7750:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 092)
Method: EM (tomography) / Resolution: 14.9 Å

EMDB-7751:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 093)
Method: EM (tomography) / Resolution: 16.5 Å

EMDB-7752:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 094)
Method: EM (tomography) / Resolution: 15.5 Å

EMDB-7753:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 095)
Method: EM (tomography) / Resolution: 14.8 Å

EMDB-7754:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 096)
Method: EM (tomography) / Resolution: 15.4 Å

EMDB-7755:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 097)
Method: EM (tomography) / Resolution: 16.1 Å

EMDB-7756:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 098)
Method: EM (tomography) / Resolution: 15.1 Å

EMDB-7757:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 099)
Method: EM (tomography) / Resolution: 15.4 Å

EMDB-7758:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 100)
Method: EM (tomography) / Resolution: 15.0 Å

EMDB-7759:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 101)
Method: EM (tomography) / Resolution: 15.0 Å

EMDB-7760:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 102)
Method: EM (tomography) / Resolution: 16.2 Å

EMDB-7761:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 103)
Method: EM (tomography) / Resolution: 15.2 Å

EMDB-7762:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 104)
Method: EM (tomography) / Resolution: 15.0 Å

EMDB-7763:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 105)
Method: EM (tomography) / Resolution: 15.1 Å

EMDB-7764:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 106)
Method: EM (tomography) / Resolution: 15.4 Å

EMDB-7765:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 107)
Method: EM (tomography) / Resolution: 15.1 Å

EMDB-7766:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 108)
Method: EM (tomography) / Resolution: 14.9 Å

EMDB-7767:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 109)
Method: EM (tomography) / Resolution: 16.0 Å

EMDB-7768:
Single-Molecule 3D Image of neurexin 1 alpha by Individual Particle Electron Tomography (No. 110)
Method: EM (tomography) / Resolution: 16.0 Å

PDB-6cw1:
Crystal structure of Neurexin-1 alpha ectodomain fragment, L2-L3
Method: X-RAY DIFFRACTION / Resolution: 2.84 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • bos taurus (cattle)
KeywordsCELL ADHESION / LNS domain / Beta-Sandwich / Synapse

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  • In this update, many items about electron microscopy experimental information are reorganized (e.g. em_software).
  • Now, EM Navigator and Yorodumi are based on the updated data.

External links:wwPDB Remediation / Enriched Model Files Conforming to OneDep Data Standards Now Available in the PDB FTP Archive

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Yorodumi Papers

Database of articles cited by EMDB/PDB/SASBDB data

  • Database of articles cited by EMDB, PDB, and SASBDB entries
  • Using PubMed data

Related info.:EMDB / PDB / SASBDB / Yorodumi / EMN Papers / Changes in new EM Navigator and Yorodumi

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