EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.
ジャーナル・号・ページ	Biochemistry, Vol. 57, Page 3934-3944, Year 2018
掲載日	2017年10月25日 (構造データの登録日)
著者	Batra, V.K. / Oertell, K. / Beard, W.A. / Kashemirov, B.A. / McKenna, C.E. / Goodman, M.F. / Wilson, S.H.
リンク	Biochemistry / PubMed:29874056
手法	X線回折
解像度	1.8 - 2.3 Å
構造データ	PDB-6bel: Ternary complex crystal structure of DNA polymerase Beta with R-isomer of beta-gamma-CHF-dCTP 手法: X-RAY DIFFRACTION / 解像度: 1.898 Å PDB-6bem: Ternary complex crystal structure of DNA polymerase Beta with S-isomer of beta-gamma-CHCL-dCTP 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-6cr3: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CBr2, beta, gamma dATP analogue 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6cr4: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with dATP 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6cr5: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CH2-beta, gamma dATP analogue 手法: X-RAY DIFFRACTION / 解像度: 1.982 Å PDB-6cr6: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CH-CH3, beta, gamma dATP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.097 Å PDB-6cr7: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHF, beta, gamma dATP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.29 Å PDB-6cr8: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHCL (R & S isomers), beta, gamma dATP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-6cr9: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CFCL, beta, gamma dATP analogue 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å PDB-6crb: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CF2, beta, gamma dATP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.151 Å PDB-6crc: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CCL2, beta, gamma dATP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-6cti: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CCL2, beta, gamma dTTP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.001 Å PDB-6ctj: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHCH3, beta, gamma dTTP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6ctk: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHF-R/S isomers, beta, gamma dTTP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.153 Å PDB-6ctl: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHCL-R/S isomers, beta, gamma dTTP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-6ctm: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHCL(R-isomer), beta, gamma dTTP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.101 Å PDB-6ctn: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CFCL,beta-gamma dTTP analogue 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-6cto: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CF2, beta, gamma dTTP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.04 Å PDB-6ctp: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CH2, beta, gamma dTTP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6ctq: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with dCTP 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-6ctr: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHF (R & S isomers), beta, gamma dCTP analogue 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6ctt: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHCL (R & S isomers, beta, gamma dCTP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-6ctu: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CFCL, beta, gamma dCTP analogue 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6ctv: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CF2, beta, gamma dCTP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-6ctw: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CCL2, beta, gamma dCTP analogue 手法: X-RAY DIFFRACTION / 解像度: 1.981 Å PDB-6ctx: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CBr2, beta, gamma dCTP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-6g2q: Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHCL (S-isomer), beta, gamma dTTP analogue 手法: X-RAY DIFFRACTION / 解像度: 2.148 Å
化合物	ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-CL: Unknown entry / クロリド / 塩化物 ChemComp-F3C: 2'-deoxy-5'-O-[(R)-{[(R)-[(R)-fluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]cytidine ChemComp-DC: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE / dCMP / dCMPYM / デオキシシチジン一リン酸 ChemComp-HOH: WATER / 水 ChemComp-DJJ: 5'-O-[(R)-{[(R)-[(S)-chloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2'-deoxycytidine ChemComp-H84: 2'-deoxy-5'-O-[(R)-{[(R)-[dibromo(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]adenosine ChemComp-DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE / dATP / デオキシアデノシン三リン酸 ChemComp-FCJ: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonomethyl)phosphoryl]oxy}phosphoryl]adenosine ChemComp-HGV: 2'-deoxy-5'-O-[(R)-hydroxy({(R)-hydroxy[(1S)-1-phosphonoethyl]phosphoryl}oxy)phosphoryl]adenosine ChemComp-V3A: 9-{2-deoxy-5-O-[(R)-{[(R)-[(R)-fluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-alpha-D-erythro-pentofuranosyl}-9H-purin-6-amine ChemComp-VA4: 5'-O-[(R)-{[(R)-[(R)-chloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2'-deoxyadenosine ChemComp-VA5: 9-{5-O-[(R)-{[(R)-[(S)-chloro(fluoro)phosphonomethyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2-deoxy-alpha-D-threo-pentofuranosyl}-9H-purin-6-amine ChemComp-VA6: 9-{2-deoxy-5-O-[(S)-{[(S)-[difluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-alpha-D-erythro-pentofuranosyl}-9H-purin-6-amine ChemComp-VA7: 2'-deoxy-5'-O-[(R)-{[(R)-[dichloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]adenosine ChemComp-VT8: 5'-O-[(R)-{[(R)-[dichloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]thymidine ChemComp-FDV: 5'-O-[(R)-hydroxy({(R)-hydroxy[(1S)-1-phosphonoethyl]phosphoryl}oxy)phosphoryl]thymidine ChemComp-FDY: 5'-O-[(R)-{[(R)-[(R)-fluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]thymidine ChemComp-FDJ: 5'-O-[(R)-{[(R)-[(R)-chloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]thymidine ChemComp-VT6: 5'-O-[(R)-{[(R)-[(S)-chloro(fluoro)phosphonomethyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]thymidine ChemComp-VT7: 5'-O-[(R)-{[(R)-[difluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]thymidine / 5′-O-[[(ホスホノジフルオロメチル)ホスホニルオキシ]ホスホニル]チミジン ChemComp-TTE: PHOSPHOMETHYL PHOSPHONIC ACID DEOXYTHYMIDYLATE ESTER / β,γ-メチレンTTP ChemComp-DCP: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE / dCTP / デオキシシチジン三リン酸 ChemComp-FF4: 2'-deoxy-5'-O-[(R)-{[(R)-[(S)-fluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]cytidine ChemComp-FF7: 5'-O-[(R)-{[(R)-[(R)-chloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2'-deoxycytidine ChemComp-VC6: 4-amino-1-{5-O-[(R)-{[(R)-[(S)-chloro(fluoro)phosphonomethyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2-deoxy-alpha-L-threo-pentofuranosyl}pyrimidin-2(1H)-one ChemComp-FFJ: 2'-deoxy-5'-O-[(R)-{[(R)-[difluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]cytidine ChemComp-VC8: 4-amino-1-{2-deoxy-5-O-[(R)-{[(R)-[dichloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-alpha-L-threo-pentofuranosyl}pyrimidin-2(1H)-one ChemComp-VC9: 2'-deoxy-5'-O-[(R)-{[(R)-[dibromo(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]cytidine ChemComp-EJH*: [(~{S})-chloranyl-[[[(2~{R},3~{S},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]methyl]phosphonic acid
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE/DNA / DNA Polymerase Beta / Conformational Change (コンフォメーション変化) / enzyme mechanism (酵素反応) / LFER (自由エネルギー関係) / TRANSFERASE-DNA complex / transcription/DNA / transcription-DNA complex / Acidity Modification / REPLICATION (DNA複製)