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-Structure paper
| Title | Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 28, Page 2029-2034, Year 2018 |
| Publish date | Mar 14, 2018 (structure data deposition date) |
 Authors | Boga, S.B. / Alhassan, A.B. / Cooper, A.B. / Doll, R. / Shih, N.Y. / Shipps, G. / Deng, Y. / Zhu, H. / Nan, Y. / Sun, R. ...Boga, S.B. / Alhassan, A.B. / Cooper, A.B. / Doll, R. / Shih, N.Y. / Shipps, G. / Deng, Y. / Zhu, H. / Nan, Y. / Sun, R. / Zhu, L. / Desai, J. / Patel, M. / Muppalla, K. / Gao, X. / Wang, J. / Yao, X. / Kelly, J. / Gudipati, S. / Paliwal, S. / Tsui, H.C. / Wang, T. / Sherborne, B. / Xiao, L. / Hruza, A. / Buevich, A. / Zhang, L.K. / Hesk, D. / Samatar, A.A. / Carr, D. / Long, B. / Black, S. / Dayananth, P. / Windsor, W. / Kirschmeier, P. / Bishop, R. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:29748051 |
| Methods | X-ray diffraction |
| Resolution | 1.85 Å |
| Structure data |  PDB-6cpw: |
| Chemicals |  ChemComp-SO4:  ChemComp-F8V:  ChemComp-HOH: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE inhibitor / TRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / MAP KINASE / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX |
rattus norvegicus (Norway rat)