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TitleAn orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 28, Page 1958-1963, Year 2018
Publish dateMar 5, 2018 (structure data deposition date)
AuthorsPrice, D.J. / Drewry, D.H. / Schaller, L.T. / Thompson, B.D. / Reid, P.R. / Maloney, P.R. / Liang, X. / Banker, P. / Buckholz, R.G. / Selley, P.K. ...Price, D.J. / Drewry, D.H. / Schaller, L.T. / Thompson, B.D. / Reid, P.R. / Maloney, P.R. / Liang, X. / Banker, P. / Buckholz, R.G. / Selley, P.K. / McDonald, O.B. / Smith, J.L. / Shearer, T.W. / Cox, R.F. / Williams, S.P. / Reid, R.A. / Tacconi, S. / Faggioni, F. / Piubelli, C. / Sartori, I. / Tessari, M. / Wang, T.Y.
External linksBioorg. Med. Chem. Lett. / PubMed:29653895
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-6cmj:
Human CAMKK2 with GSK650393
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-F6J:
2-(2-methylpropyl)-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid

ChemComp-FMT:
FORMIC ACID

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / kinase / signaling protein / TRANSFERASE-TRANSFERASE INHIBITOR complex

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