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Structure paper

TitleThe Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations inStaphylococcus aureusDihydropteroate Synthase.
Journal, issue, pagesFront Microbiol, Vol. 9, Page 1369-1369, Year 2018
Publish dateMar 2, 2018 (structure data deposition date)
AuthorsGriffith, E.C. / Wallace, M.J. / Wu, Y. / Kumar, G. / Gajewski, S. / Jackson, P. / Phelps, G.A. / Zheng, Z. / Rock, C.O. / Lee, R.E. / White, S.W.
External linksFront Microbiol / PubMed:30065703
MethodsX-ray diffraction
Resolution1.95 - 2.3 Å
Structure data

PDB-6clu:
Staphylococcus aureus Dihydropteroate Synthase (saDHPS) F17L E208K double mutant structure
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-6clv:
Staphylococcus aureus Dihydropteroate Synthase (saDHPS) F17L E208K double mutant structure
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-6MB:
4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide

Source
  • staphylococcus aureus (bacteria)
KeywordsANTIMICROBIAL PROTEIN / antibiotic resistance mutations / sulfonamide resistance

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