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Structure paper

TitleLLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.
Journal, issue, pagesACS Med Chem Lett, Vol. 9, Page 612-617, Year 2018
Publish dateFeb 27, 2018 (structure data deposition date)
AuthorsBonday, Z.Q. / Cortez, G.S. / Grogan, M.J. / Antonysamy, S. / Weichert, K. / Bocchinfuso, W.P. / Li, F. / Kennedy, S. / Li, B. / Mader, M.M. ...Bonday, Z.Q. / Cortez, G.S. / Grogan, M.J. / Antonysamy, S. / Weichert, K. / Bocchinfuso, W.P. / Li, F. / Kennedy, S. / Li, B. / Mader, M.M. / Arrowsmith, C.H. / Brown, P.J. / Eram, M.S. / Szewczyk, M.M. / Barsyte-Lovejoy, D. / Vedadi, M. / Guccione, E. / Campbell, R.M.
External linksACS Med Chem Lett / PubMed:30034588
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-6ckc:
Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-F5J:
7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Inhibitor / Complex

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