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| Title | Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase gamma (PI3K gamma ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS). |
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| Journal, issue, pages | J. Med. Chem., Vol. 61, Page 5245-5256, Year 2018 |
| Publish date | Jan 5, 2018 (structure data deposition date) |
 Authors | Come, J.H. / Collier, P.N. / Henderson, J.A. / Pierce, A.C. / Davies, R.J. / Le Tiran, A. / O'Dowd, H. / Bandarage, U.K. / Cao, J. / Deininger, D. ...Come, J.H. / Collier, P.N. / Henderson, J.A. / Pierce, A.C. / Davies, R.J. / Le Tiran, A. / O'Dowd, H. / Bandarage, U.K. / Cao, J. / Deininger, D. / Grey, R. / Krueger, E.B. / Lowe, D.B. / Liang, J. / Liao, Y. / Messersmith, D. / Nanthakumar, S. / Sizensky, E. / Wang, J. / Xu, J. / Chin, E.Y. / Damagnez, V. / Doran, J.D. / Dworakowski, W. / Griffith, J.P. / Jacobs, M.D. / Khare-Pandit, S. / Mahajan, S. / Moody, C.S. / Aronov, A.M. |
 External links | J. Med. Chem. / PubMed:29847724 |
| Methods | X-ray diffraction |
| Resolution | 2.31 Å |
| Structure data |  PDB-6c1s: |
| Chemicals |  ChemComp-EFV:  ChemComp-SO4:  ChemComp-HOH: |
| Source |
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 Keywords | Transferase/Transferase Inhibitor / kinase / inhibitor / Transferase-Transferase Inhibitor complex |
homo sapiens (human)