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-Structure paper
Title | Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 28, Page 987-992, Year 2018 |
Publish date | Jan 2, 2018 (structure data deposition date) |
Authors | Hu, Z. / Wang, C. / Han, W. / Rossi, K.A. / Bozarth, J.M. / Wu, Y. / Sheriff, S. / Myers, J.E. / Luettgen, J.M. / Seiffert, D.A. ...Hu, Z. / Wang, C. / Han, W. / Rossi, K.A. / Bozarth, J.M. / Wu, Y. / Sheriff, S. / Myers, J.E. / Luettgen, J.M. / Seiffert, D.A. / Wexler, R.R. / Quan, M.L. |
External links | Bioorg. Med. Chem. Lett. / PubMed:29501396 |
Methods | X-ray diffraction |
Resolution | 2.35 Å |
Structure data | PDB-6c0s: |
Chemicals | ChemComp-EEJ: ChemComp-SO4: ChemComp-EDO: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex / serine protease / blood coagulation factor / protein inhibitor complex |