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-Structure paper
Title | Global conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions. |
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Journal, issue, pages | Biochem. J., Vol. 475, Page 2179-2190, Year 2018 |
Publish date | Dec 22, 2017 (structure data deposition date) |
Authors | Burvenich, I.J.G. / Farrugia, W. / Liu, Z. / Makris, D. / King, D. / Gloria, B. / Perani, A. / Allan, L.C. / Scott, A.M. / Ramsland, P.A. |
External links | Biochem. J. / PubMed:29794155 |
Methods | X-ray diffraction |
Resolution | 2.4 Å |
Structure data | PDB-6bz4: |
Chemicals | ChemComp-EDO: ChemComp-HOH: |
Source |
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Keywords | IMMUNE SYSTEM / Immunoglobulin G / Fc engineering / complement dependent cytotoxicity |