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-Structure paper
Title | Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 6002-6017, Year 2018 |
Publish date | Dec 13, 2017 (structure data deposition date) |
Authors | Abbott, J.R. / Hodges, T.R. / Daniels, R.N. / Patel, P.A. / Kennedy, J.P. / Howes, J.E. / Akan, D.T. / Burns, M.C. / Sai, J. / Sobolik, T. ...Abbott, J.R. / Hodges, T.R. / Daniels, R.N. / Patel, P.A. / Kennedy, J.P. / Howes, J.E. / Akan, D.T. / Burns, M.C. / Sai, J. / Sobolik, T. / Beesetty, Y. / Lee, T. / Rossanese, O.W. / Phan, J. / Waterson, A.G. / Fesik, S.W. |
External links | J. Med. Chem. / PubMed:29856609 |
Methods | X-ray diffraction |
Resolution | 1.746 - 1.799 Å |
Structure data | PDB-6bvi: PDB-6bvj: PDB-6bvk: PDB-6bvl: PDB-6bvm: |
Chemicals | ChemComp-GNP: ChemComp-MG: ChemComp-EC4: ChemComp-FMT: ChemComp-GOL: ChemComp-NA: ChemComp-HOH: ChemComp-EAS: ChemComp-EAV: ChemComp-EBY: ChemComp-EBV: |
Source |
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Keywords | SIGNALING PROTEIN / Ras / SOS / inhibitor / ONCOPROTEIN / Protein-protein complex / MAPK |