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TitleDiscovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 28, Page 1336-1341, Year 2018
Publish dateDec 3, 2017 (structure data deposition date)
AuthorsGingipalli, L. / Block, M.H. / Bao, L. / Cooke, E. / Dakin, L.A. / Denz, C.R. / Ferguson, A.D. / Johannes, J.W. / Larsen, N.A. / Lyne, P.D. ...Gingipalli, L. / Block, M.H. / Bao, L. / Cooke, E. / Dakin, L.A. / Denz, C.R. / Ferguson, A.D. / Johannes, J.W. / Larsen, N.A. / Lyne, P.D. / Pontz, T.W. / Wang, T. / Wu, X. / Wu, A. / Zhang, H.J. / Zheng, X. / Dowling, J.E. / Lamb, M.L.
External linksBioorg. Med. Chem. Lett. / PubMed:29559278
MethodsX-ray diffraction
Resolution2.573 Å
Structure data

PDB-6bsk:
Human PIM1 kinase in complex with compound 12b
Method: X-RAY DIFFRACTION / Resolution: 2.573 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-MVG:
4-{6-[6-(propan-2-ylamino)-1H-indazol-1-yl]pyrazin-2-yl}benzoic acid

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE Inhibitor / Kinase / PIM1 / inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE Inhibitor complex

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