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-Structure paper
Title | Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition. |
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Journal, issue, pages | Mol. Pharmacol., Vol. 94, Page 1210-1219, Year 2018 |
Publish date | Jun 15, 2017 (structure data deposition date) |
Authors | Beyett, T.S. / Gan, X. / Reilly, S.M. / Chang, L. / Gomez, A.V. / Saltiel, A.R. / Showalter, H.D. / Tesmer, J.J.G. |
External links | Mol. Pharmacol. / PubMed:30082428 |
Methods | X-ray diffraction |
Resolution | 3.197 - 3.645 Å |
Structure data | PDB-5w5v: PDB-6bny: PDB-6bod: PDB-6boe: |
Chemicals | ChemComp-ANW: ChemComp-E0M: ChemComp-E0P: ChemComp-E0S: |
Source |
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Keywords | TRANSFERASE / TBK1 / kinase / amlexanox / obesity / diabetes / TRANSFERASE/INHIBITOR / TRANSFERASE-INHIBITOR complex |