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-Structure paper
Title | Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 25, Page 6479-6485, Year 2017 |
Publish date | Nov 16, 2017 (structure data deposition date) |
![]() | LaRochelle, J.R. / Fodor, M. / Ellegast, J.M. / Liu, X. / Vemulapalli, V. / Mohseni, M. / Stams, T. / Buhrlage, S.J. / Stegmaier, K. / LaMarche, M.J. ...LaRochelle, J.R. / Fodor, M. / Ellegast, J.M. / Liu, X. / Vemulapalli, V. / Mohseni, M. / Stams, T. / Buhrlage, S.J. / Stegmaier, K. / LaMarche, M.J. / Acker, M.G. / Blacklow, S.C. |
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Methods | X-ray diffraction |
Resolution | 2.22 Å |
Structure data | ![]() PDB-6bn5: |
Chemicals | ![]() ChemComp-DZJ: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / SHP2 / PTPN11 / protein tyrosine phosphatase / phosphatase / allosteric inhibitor / HYDROLASE-HYDROLASE INHIBITOR complex |