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-Structure paper
Title | NAD+analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains. |
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Journal, issue, pages | Nat Commun, Vol. 9, Page 844-844, Year 2018 |
Publish date | Oct 31, 2017 (structure data deposition date) |
Authors | Langelier, M.F. / Zandarashvili, L. / Aguiar, P.M. / Black, B.E. / Pascal, J.M. |
External links | Nat Commun / PubMed:29487285 |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | PDB-6bhv: |
Chemicals | ChemComp-DQV: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / PARP-1 / ARTD1 / poly(ADP-ribose) polymerase / non-hydrolyzable NAD+ analog / PARP / ADP-ribose |