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-Structure paper
Title | Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 9807-9820, Year 2017 |
Publish date | Oct 26, 2017 (structure data deposition date) |
![]() | Bueno, A.B. / Agejas, J. / Broughton, H. / Dally, R. / Durham, T.B. / Espinosa, J.F. / Gonzalez, R. / Hahn, P.J. / Marcos, A. / Rodriguez, R. ...Bueno, A.B. / Agejas, J. / Broughton, H. / Dally, R. / Durham, T.B. / Espinosa, J.F. / Gonzalez, R. / Hahn, P.J. / Marcos, A. / Rodriguez, R. / Sanz, G. / Soriano, J.F. / Timm, D. / Vidal, P. / Yang, H.C. / McCarthy, J.R. |
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Methods | X-ray diffraction |
Resolution | 1.51 - 1.99 Å |
Structure data | ![]() PDB-6bfd: ![]() PDB-6bfe: ![]() PDB-6bfw: ![]() PDB-6bfx: |
Chemicals | ![]() ChemComp-DJS: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-DJV: ![]() ChemComp-DK7: ![]() ChemComp-DKJ: |
Source |
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![]() | HYDROLASE/HYDROLASE Inhibitor / BACE1 / beta-secretase / inhibitor / protease / HYDROLASE / HYDROLASE-HYDROLASE Inhibitor complex |