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TitleInherent steroid 17 alpha ,20-lyase activity in defunct cytochrome P450 17A enzymes.
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 541-556, Year 2018
Publish dateOct 5, 2017 (structure data deposition date)
AuthorsGonzalez, E. / Johnson, K.M. / Pallan, P.S. / Phan, T.T.N. / Zhang, W. / Lei, L. / Wawrzak, Z. / Yoshimoto, F.K. / Egli, M. / Guengerich, F.P.
External linksJ. Biol. Chem. / PubMed:29212707
MethodsX-ray diffraction
Resolution3.03 Å
Structure data

PDB-6b82:
Zebra Fish CYP-450 17A1 Mutant Abiraterone Complex
Method: X-RAY DIFFRACTION / Resolution: 3.03 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-AER:
Abiraterone / medication*YM

ChemComp-ACT:
ACETATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • danio rerio (zebrafish)
KeywordsOXIDOREDUCTASE / CYTOCHROME P450 / CYP17A1 mutant / P450 17A1 / MONOOXYGENASE / 17A-HYDROXYLASE / HEME PROTEIN / CYTOCHROME P450 OXIDOREDUCTASE / ABIRATERONE / 17A-HYDROXYLATION / MEMBRANE / MICROSOME / ENDOPLASMIC RETICULUM

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