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Title | Synthesis and Pharmacological Characterization of C4beta-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3Receptor Agonist. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 2303-2328, Year 2018 |
Publish date | Oct 4, 2017 (structure data deposition date) |
Authors | Monn, J.A. / Henry, S.S. / Massey, S.M. / Clawson, D.K. / Chen, Q. / Diseroad, B.A. / Bhardwaj, R.M. / Atwell, S. / Lu, F. / Wang, J. ...Monn, J.A. / Henry, S.S. / Massey, S.M. / Clawson, D.K. / Chen, Q. / Diseroad, B.A. / Bhardwaj, R.M. / Atwell, S. / Lu, F. / Wang, J. / Russell, M. / Heinz, B.A. / Wang, X.S. / Carter, J.H. / Getman, B.G. / Adragni, K. / Broad, L.M. / Sanger, H.E. / Ursu, D. / Catlow, J.T. / Swanson, S. / Johnson, B.G. / Shaw, D.B. / McKinzie, D.L. / Hao, J. |
External links | J. Med. Chem. / PubMed:29350927 |
Methods | X-ray diffraction |
Resolution | 2.82 Å |
Structure data | PDB-6b7h: |
Chemicals | ChemComp-NAG: ChemComp-CWY: ChemComp-CA: ChemComp-HOH: |
Source |
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Keywords | MEMBRANE PROTEIN/AGONIST / mGluR3 Glutamate / MEMBRANE PROTEIN-AGONIST complex |