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-Structure paper
Title | Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. |
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Journal, issue, pages | Angew. Chem. Int. Ed. Engl., Vol. 57, Page 1601-1605, Year 2018 |
Publish date | Sep 25, 2017 (structure data deposition date) |
Authors | Xu, S. / Aguilar, A. / Xu, T. / Zheng, K. / Huang, L. / Stuckey, J. / Chinnaswamy, K. / Bernard, D. / Fernandez-Salas, E. / Liu, L. ...Xu, S. / Aguilar, A. / Xu, T. / Zheng, K. / Huang, L. / Stuckey, J. / Chinnaswamy, K. / Bernard, D. / Fernandez-Salas, E. / Liu, L. / Wang, M. / McEachern, D. / Przybranowski, S. / Foster, C. / Wang, S. |
External links | Angew. Chem. Int. Ed. Engl. / PubMed:29284071 |
Methods | X-ray diffraction |
Resolution | 2.61 Å |
Structure data | PDB-6b41: |
Chemicals | ChemComp-CJV: ChemComp-7PR: ChemComp-HOH: |
Source |
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Keywords | PROTEIN BINDING/INHIBITOR / Covalent Inhibitor / MEN1 syndrome / leukemia / PROTEIN BINDING-INHIBITOR complex |