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-Structure paper
Title | Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 8, Page 1116-1121, Year 2017 |
Publish date | Sep 15, 2017 (structure data deposition date) |
![]() | Cho, Y.S. / Levell, J.R. / Liu, G. / Caferro, T. / Sutton, J. / Shafer, C.M. / Costales, A. / Manning, J.R. / Zhao, Q. / Sendzik, M. ...Cho, Y.S. / Levell, J.R. / Liu, G. / Caferro, T. / Sutton, J. / Shafer, C.M. / Costales, A. / Manning, J.R. / Zhao, Q. / Sendzik, M. / Shultz, M. / Chenail, G. / Dooley, J. / Villalba, B. / Farsidjani, A. / Chen, J. / Kulathila, R. / Xie, X. / Dodd, S. / Gould, T. / Liang, G. / Heimbach, T. / Slocum, K. / Firestone, B. / Pu, M. / Pagliarini, R. / Growney, J.D. |
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Methods | X-ray diffraction |
Resolution | 2.334 Å |
Structure data | ![]() PDB-6b0z: |
Chemicals | ![]() ChemComp-NDP: ![]() ChemComp-C81: ![]() ChemComp-FLC: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE / Isocitrate dehydrogenase / Rossmann fold / NADPH / inhibitor |