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TitleDiscovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.
Journal, issue, pagesJ. Med. Chem., Vol. 61, Page 2837-2864, Year 2018
Publish dateSep 14, 2017 (structure data deposition date)
AuthorsTria, G.S. / Abrams, T. / Baird, J. / Burks, H.E. / Firestone, B. / Gaither, L.A. / Hamann, L.G. / He, G. / Kirby, C.A. / Kim, S. ...Tria, G.S. / Abrams, T. / Baird, J. / Burks, H.E. / Firestone, B. / Gaither, L.A. / Hamann, L.G. / He, G. / Kirby, C.A. / Kim, S. / Lombardo, F. / Macchi, K.J. / McDonnell, D.P. / Mishina, Y. / Norris, J.D. / Nunez, J. / Springer, C. / Sun, Y. / Thomsen, N.M. / Wang, C. / Wang, J. / Yu, B. / Tiong-Yip, C.L. / Peukert, S.
External linksJ. Med. Chem. / PubMed:29562737
MethodsX-ray diffraction
Resolution2.86 Å
Structure data

PDB-6b0f:
ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH LSZ102
Method: X-RAY DIFFRACTION / Resolution: 2.86 Å

Chemicals

ChemComp-C6V:
LSZ102

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHORMONE RECEPTOR / nuclear receptor

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