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-Structure paper
Title | Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma. |
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Journal, issue, pages | ACS Chem. Biol., Vol. 13, Page 933-941, Year 2018 |
Publish date | Aug 25, 2017 (structure data deposition date) |
Authors | Huard, D.J.E. / Crowley, V.M. / Du, Y. / Cordova, R.A. / Sun, Z. / Tomlin, M.O. / Dickey, C.A. / Koren, J. / Blair, L. / Fu, H. ...Huard, D.J.E. / Crowley, V.M. / Du, Y. / Cordova, R.A. / Sun, Z. / Tomlin, M.O. / Dickey, C.A. / Koren, J. / Blair, L. / Fu, H. / Blagg, B.S.J. / Lieberman, R.L. |
External links | ACS Chem. Biol. / PubMed:29402077 |
Methods | X-ray diffraction |
Resolution | 2.35 - 2.696 Å |
Structure data | PDB-6asp: PDB-6asq: |
Chemicals | ChemComp-P33: ChemComp-GOL: ChemComp-V2C: ChemComp-HOH: ChemComp-PE8: ChemComp-PEG: ChemComp-VC4: |
Source |
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Keywords | CHAPERONE/INHIBITOR / Grp94 / Hsp90 / Inhibitor / Glaucoma / CHAPERONE-INHIBITOR complex |