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Structure paper

TitleAirway relaxation mechanisms and structural basis of osthole for improving lung function in asthma.
Journal, issue, pagesSci. Signal., Vol. 13, Year 2020
Publish dateSep 3, 2018 (structure data deposition date)
AuthorsWang, S. / Xie, Y. / Huo, Y.W. / Li, Y. / Abel, P.W. / Jiang, H. / Zou, X. / Jiao, H.Z. / Kuang, X. / Wolff, D.W. ...Wang, S. / Xie, Y. / Huo, Y.W. / Li, Y. / Abel, P.W. / Jiang, H. / Zou, X. / Jiao, H.Z. / Kuang, X. / Wolff, D.W. / Huang, Y.G. / Casale, T.B. / Panettieri Jr., R.A. / Wei, T. / Cao, Z. / Tu, Y.
External linksSci. Signal. / PubMed:33234690
MethodsX-ray diffraction
Resolution2.326 Å
Structure data

PDB-6akr:
Crystal structure of the PDE4D catalytic domain in complex with osthole
Method: X-RAY DIFFRACTION / Resolution: 2.326 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-A0O:
7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / phosphodiesterase 4d

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