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-Structure paper
Title | Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors |
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Journal, issue, pages | Eur J Med Chem, Vol. 163, Page 281-294, Year 2018 |
Publish date | Aug 8, 2018 (structure data deposition date) |
Authors | Xing, J. / Zhang, R. / Jiang, X. / Hu, T. / Wang, X. / Qiao, G. / Wang, J. / Yang, F. / Luo, X. / Chen, K. ...Xing, J. / Zhang, R. / Jiang, X. / Hu, T. / Wang, X. / Qiao, G. / Wang, J. / Yang, F. / Luo, X. / Chen, K. / Shen, J. / Luo, C. / Jiang, H. / Zheng, M. |
External links | Eur J Med Chem / PubMed:30529546 |
Methods | X-ray diffraction |
Resolution | 1.998 Å |
Structure data | PDB-6afr: |
Chemicals | ChemComp-9E3: ChemComp-HOH: |
Source |
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Keywords | Signaling protein/inhibitor / Brd4 / epigenetic / SIGNALING PROTEIN-INHIBITOR complex |