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TitleLenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models.
Journal, issue, pagesCancer Med, Vol. 7, Page 2641-2653, Year 2018
Publish dateMay 9, 2018 (structure data deposition date)
AuthorsMatsuki, M. / Hoshi, T. / Yamamoto, Y. / Ikemori-Kawada, M. / Minoshima, Y. / Funahashi, Y. / Matsui, J.
External linksCancer Med / PubMed:29733511
MethodsX-ray diffraction
Resolution2.86 Å
Structure data

PDB-5zv2:
FGFR-1 in complex with ligand lenvatinib
Method: X-RAY DIFFRACTION / Resolution: 2.86 Å

Chemicals

ChemComp-LEV:
4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide / medication, anticancer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / FGF RECEPTOR KINASE / TRANSFERASE-TRANSFERASE INHIBITOR complex / BIOSYNTHETIC PROTEIN

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