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TitleStructural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells.
Journal, issue, pagesMol. Cancer Ther., Vol. 18, Page 1484-1496, Year 2019
Publish dateApr 2, 2018 (structure data deposition date)
AuthorsAnantharajan, J. / Zhou, H. / Zhang, L. / Hotz, T. / Vincent, M.Y. / Blevins, M.A. / Jansson, A.E. / Kuan, J.W.L. / Ng, E.Y. / Yeo, Y.K. ...Anantharajan, J. / Zhou, H. / Zhang, L. / Hotz, T. / Vincent, M.Y. / Blevins, M.A. / Jansson, A.E. / Kuan, J.W.L. / Ng, E.Y. / Yeo, Y.K. / Baburajendran, N. / Lin, G. / Hung, A.W. / Joy, J. / Patnaik, S. / Marugan, J. / Rudra, P. / Ghosh, D. / Hill, J. / Keller, T.H. / Zhao, R. / Ford, H.L. / Kang, C.
External linksMol. Cancer Ther. / PubMed:31285279
MethodsX-ray diffraction
Resolution3.175 Å
Structure data

PDB-5zma:
Structural basis for an allosteric Eya2 phosphatase inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.175 Å

Chemicals

ChemComp-9FX:
3-fluoro-N'-[(E)-{5-[(pyrimidin-2-yl)sulfanyl]furan-2-yl}methylidene]benzohydrazide

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / eya2 / eyes absent protein / phosphatase / transcription coactivator

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