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TitleORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2).
Journal, issue, pagesMol. Cell, Vol. 73, Page 458-473.e7, Year 2019
Publish dateApr 1, 2018 (structure data deposition date)
AuthorsWang, H. / Ma, Q. / Qi, Y. / Dong, J. / Du, X. / Rae, J. / Wang, J. / Wu, W.F. / Brown, A.J. / Parton, R.G. ...Wang, H. / Ma, Q. / Qi, Y. / Dong, J. / Du, X. / Rae, J. / Wang, J. / Wu, W.F. / Brown, A.J. / Parton, R.G. / Wu, J.W. / Yang, H.
External linksMol. Cell / PubMed:30581148
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-5zm8:
Crystal structure of ORP2-ORD in complex with PI(4,5)P2
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-IEP:
[(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIPID TRANSPORT / Transporter / Complex / Phospholipid

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