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Structure paper

TitleEnzymology of Anthraquinone-gamma-Pyrone Ring Formation in Complex Aromatic Polyketide Biosynthesis.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 57, Page 13475-13479, Year 2018
Publish dateJan 5, 2018 (structure data deposition date)
AuthorsHou, X.F. / Song, Y.J. / Zhang, M. / Lan, W.X. / Meng, S. / Wang, C.X. / Pan, H.X. / Cao, C.Y. / Tang, G.L.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:30151879
MethodsNMR (solution)
Structure data

PDB-5z36:
An anthrahydroquino-Gama-pyrone synthase Txn09 complexed with PDM
Method: SOLUTION NMR

PDB-5z4e:
An anthrahydroquino-Gama-pyrone synthase Txn09
Method: SOLUTION NMR

PDB-5z4f:
An anthrahydroquino-Gama-pyrone synthase Txn09 complexed with SUM
Method: SOLUTION NMR

Chemicals

ChemComp-969:
11-hydroxy-2-[(2S)-2-hydroxybutan-2-yl]-5-methyl-4H-anthra[1,2-b]pyran-4,7,12-trione

ChemComp-96F:
1,8-dihydroxy-2-[(4R)-4-hydroxy-4-methyl-3-oxohexanoyl]-3-methylanthracene-9,10-dione

Source
  • streptomyces bottropensis (bacteria)
KeywordsBIOSYNTHETIC PROTEIN / type II polyketide heterocyclase / enzyme mechanism / natural product / Streptomyces bottropensis

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