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Structure paper

TitleAlpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.
Journal, issue, pagesNature, Vol. 561, Page 122-126, Year 2018
Publish dateJan 2, 2018 (structure data deposition date)
AuthorsZhou, P. / She, Y. / Dong, N. / Li, P. / He, H. / Borio, A. / Wu, Q. / Lu, S. / Ding, X. / Cao, Y. ...Zhou, P. / She, Y. / Dong, N. / Li, P. / He, H. / Borio, A. / Wu, Q. / Lu, S. / Ding, X. / Cao, Y. / Xu, Y. / Gao, W. / Dong, M. / Ding, J. / Wang, D.C. / Zamyatina, A. / Shao, F.
External linksNature / PubMed:30111836
MethodsX-ray diffraction
Resolution2.594 Å
Structure data

PDB-5z2c:
Crystal structure of ALPK-1 N-terminal domain in complex with ADP-heptose
Method: X-RAY DIFFRACTION / Resolution: 2.594 Å

Chemicals

ChemComp-AYU:
[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2S,3S,4S,5S,6R)-6-[(1S)-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl] hydrogen phosphate

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / pattern recognition receptor / kinase

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