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-Structure paper
| Title | Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3. |
|---|---|
| Journal, issue, pages | Acs Med. Chem. Lett., Vol. 10, Page 978-984, Year 2019 |
| Publish date | Oct 11, 2017 (structure data deposition date) |
 Authors | Huang, C. / Liew, S.S. / Lin, G.R. / Poulsen, A. / Ang, M.J.Y. / Chia, B.C.S. / Chew, S.Y. / Kwek, Z.P. / Wee, J.L.K. / Ong, E.H. ...Huang, C. / Liew, S.S. / Lin, G.R. / Poulsen, A. / Ang, M.J.Y. / Chia, B.C.S. / Chew, S.Y. / Kwek, Z.P. / Wee, J.L.K. / Ong, E.H. / Retna, P. / Baburajendran, N. / Li, R. / Yu, W. / Koh-Stenta, X. / Ngo, A. / Manesh, S. / Fulwood, J. / Ke, Z. / Chung, H.H. / Sepramaniam, S. / Chew, X.H. / Dinie, N. / Lee, M.A. / Chew, Y.S. / Low, C.B. / Pendharkar, V. / Manoharan, V. / Vuddagiri, S. / Sangthongpitag, K. / Joy, J. / Matter, A. / Hill, J. / Keller, T.H. / Foo, K. |
 External links | Acs Med. Chem. Lett. / PubMed:31223458 |
| Methods | X-ray diffraction |
| Resolution | 2.135 - 2.351 Å |
| Structure data |  PDB-5yjo:  PDB-6ijl: |
| Chemicals |  ChemComp-ZN:  ChemComp-8W0:  ChemComp-SAM:  ChemComp-HOH:  ChemComp-A8U: |
| Source |
|
 Keywords | TRANSFERASE/INHIBITOR / covalent inhibitor / methyltransferase / methyltransferase inhibitor / TRANSFERASE-INHIBITOR complex |
homo sapiens (human)