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TitleDiscovery, optimization and biological evaluation for novel c-Met kinase inhibitors
Journal, issue, pagesEur J Med Chem, Vol. 143, Page 491-502, Year 2018
Publish dateAug 30, 2017 (structure data deposition date)
AuthorsYuan, H. / Liu, Q. / Zhang, L. / Hu, S. / Chen, T. / Li, H. / Chen, Y. / Xu, Y. / Lu, T.
External linksEur J Med Chem / PubMed:29202410
MethodsX-ray diffraction
Resolution1.89 Å
Structure data

PDB-5ya5:
CRYSTAL STRUCTURE OF c-MET IN COMPLEX WITH NOVEL INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

Chemicals

ChemComp-6TD:
2-[3-(4-methoxybenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-1H-indole

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/INHIBITOR / c-MET inhibitor / TRANSFERASE-INHIBITOR complex

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