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| Title | Potent mechanism-based sirtuin-2-selective inhibition by anin situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site. |
|---|---|
| Journal, issue, pages | Chem Sci, Vol. 8, Page 6400-6408, Year 2017 |
| Publish date | Aug 9, 2017 (structure data deposition date) |
Authors | Mellini, P. / Itoh, Y. / Tsumoto, H. / Li, Y. / Suzuki, M. / Tokuda, N. / Kakizawa, T. / Miura, Y. / Takeuchi, J. / Lahtela-Kakkonen, M. / Suzuki, T. |
External links | Chem Sci / PubMed:28989670 |
| Methods | X-ray diffraction |
| Resolution | 2.3 Å |
| Structure data | ![]() PDB-5y5n: |
| Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-8NO: ![]() ChemComp-HOH: |
| Source |
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Keywords | HYDROLASE/INHIBITOR / Pseudopeptides / Anticancer activity / Neurite outgrowth / HYDROLASE-INHIBITOR complex |
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