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-Structure paper
Title | Discovery of potent and selective CDK8 inhibitors through FBDD approach |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 27, Page 4488-4492, Year 2017 |
Publish date | Jun 7, 2017 (structure data deposition date) |
![]() | Han, X. / Jiang, M. / Zhou, C. / Zhou, Z. / Xu, Z. / Wang, L. / Mayweg, A.V. / Niu, R. / Jin, T.G. / Yang, S. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.04 - 2.3 Å |
Structure data | ![]() PDB-5xqx: ![]() PDB-5xs2: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-8CC: ![]() ChemComp-HOH: ![]() ChemComp-8D6: |
Source |
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![]() | TRANSFERASE / CDK8 / CYCLIN C / MEDIATOR COMPLEX |