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Structure paper

TitleInhibition of homoserine dehydrogenase by formation of a cysteine-NAD covalent complex
Journal, issue, pagesSci Rep, Vol. 8, Page 5749-5749, Year 2018
Publish dateMar 6, 2017 (structure data deposition date)
AuthorsOgata, K. / Yajima, Y. / Nakamura, S. / Kaneko, R. / Goto, M. / Ohshima, T. / Yoshimune, K.
External linksSci Rep / PubMed:29636528
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-5x9d:
Crystal structure of homoserine dehydrogenase in complex with L-cysteine and NAD
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-80F:
(2R)-3-[[(4S)-3-aminocarbonyl-1-[(2R,3R,4S,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]-4H-pyridin-4-yl]sulfanyl]-2-azanyl-propanoic acid

ChemComp-TLA:
L(+)-TARTARIC ACID

ChemComp-HOH:
WATER

Source
  • sulfolobus tokodaii (strain dsm 16993 / jcm 10545 / nbrc 100140 / 7) (archaea)
KeywordsOXIDOREDUCTASE / Complex / Inhibitor

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