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-Structure paper
Title | Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 25, Page 3540-3546, Year 2017 |
Publish date | Jan 27, 2017 (structure data deposition date) |
![]() | Matsui, Y. / Yasumatsu, I. / Asahi, T. / Kitamura, T. / Kanai, K. / Ubukata, O. / Hayasaka, H. / Takaishi, S. / Hanzawa, H. / Katakura, S. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.1 - 3 Å |
Structure data | ![]() PDB-5x1v: ![]() PDB-5x1w: |
Chemicals | ![]() ChemComp-FBP: ![]() ChemComp-7XX: ![]() ChemComp-HOH: ![]() ChemComp-7Y0: |
Source |
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![]() | TRANSFERASE / activator / complex |