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TitleCharacterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 3535-3545, Year 2018
Publish dateJul 21, 2017 (structure data deposition date)
AuthorsHuang, Q. / Stalnecker, C. / Zhang, C. / McDermott, L.A. / Iyer, P. / O'Neill, J. / Reimer, S. / Cerione, R.A. / Katt, W.P.
External linksJ. Biol. Chem. / PubMed:29317493
MethodsX-ray diffraction
Resolution2.445 Å
Structure data

PDB-5wj6:
Crystal structure of glutaminase C in complex with inhibitor 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (UPGL-00004)
Method: X-RAY DIFFRACTION / Resolution: 2.445 Å

Chemicals

ChemComp-B4A:
2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / glutaminase C / inhibitor / complex / glutamine / HYDROLASE-HYDROLASE INHIBITOR complex

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