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Title | Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 9617-9629, Year 2017 |
Publish date | Jul 18, 2017 (structure data deposition date) |
Authors | Crosignani, S. / Bingham, P. / Bottemanne, P. / Cannelle, H. / Cauwenberghs, S. / Cordonnier, M. / Dalvie, D. / Deroose, F. / Feng, J.L. / Gomes, B. ...Crosignani, S. / Bingham, P. / Bottemanne, P. / Cannelle, H. / Cauwenberghs, S. / Cordonnier, M. / Dalvie, D. / Deroose, F. / Feng, J.L. / Gomes, B. / Greasley, S. / Kaiser, S.E. / Kraus, M. / Negrerie, M. / Maegley, K. / Miller, N. / Murray, B.W. / Schneider, M. / Soloweij, J. / Stewart, A.E. / Tumang, J. / Torti, V.R. / Van Den Eynde, B. / Wythes, M. |
External links | J. Med. Chem. / PubMed:29111717 |
Methods | X-ray diffraction |
Resolution | 2.28 Å |
Structure data | PDB-5whr: |
Chemicals | ChemComp-HEM: ChemComp-AOJ: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE/Inhibitor / Cancer immunotherapy / Small molecule inhibitor / OXIDOREDUCTASE / OXIDOREDUCTASE-Inhibitor complex |