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TitleDiscovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.
Journal, issue, pagesJ. Med. Chem., Vol. 60, Page 9617-9629, Year 2017
Publish dateJul 18, 2017 (structure data deposition date)
AuthorsCrosignani, S. / Bingham, P. / Bottemanne, P. / Cannelle, H. / Cauwenberghs, S. / Cordonnier, M. / Dalvie, D. / Deroose, F. / Feng, J.L. / Gomes, B. ...Crosignani, S. / Bingham, P. / Bottemanne, P. / Cannelle, H. / Cauwenberghs, S. / Cordonnier, M. / Dalvie, D. / Deroose, F. / Feng, J.L. / Gomes, B. / Greasley, S. / Kaiser, S.E. / Kraus, M. / Negrerie, M. / Maegley, K. / Miller, N. / Murray, B.W. / Schneider, M. / Soloweij, J. / Stewart, A.E. / Tumang, J. / Torti, V.R. / Van Den Eynde, B. / Wythes, M.
External linksJ. Med. Chem. / PubMed:29111717
MethodsX-ray diffraction
Resolution2.28 Å
Structure data

PDB-5whr:
Discovery of a novel and selective IDO-1 inhibitor PF-06840003 and its characterization as a potential clinical candidate.
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-AOJ:
(3R)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE/Inhibitor / Cancer immunotherapy / Small molecule inhibitor / OXIDOREDUCTASE / OXIDOREDUCTASE-Inhibitor complex

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