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-Structure paper
Title | High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. |
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Journal, issue, pages | Anal. Biochem., Vol. 548, Page 44-52, Year 2018 |
Publish date | Jul 12, 2017 (structure data deposition date) |
![]() | Burns, M.C. / Howes, J.E. / Sun, Q. / Little, A.J. / Camper, D.V. / Abbott, J.R. / Phan, J. / Lee, T. / Waterson, A.G. / Rossanese, O.W. / Fesik, S.W. |
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Methods | X-ray diffraction |
Resolution | 1.99 - 2.46 Å |
Structure data | ![]() PDB-5wfo: ![]() PDB-5wfp: ![]() PDB-5wfq: ![]() PDB-5wfr: |
Chemicals | ![]() ChemComp-MG: ![]() ChemComp-GNP: ![]() ChemComp-5UU: ![]() ChemComp-HOH: ![]() ChemComp-5UX: ![]() ChemComp-5UV: ![]() ChemComp-5UW: |
Source |
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![]() | SIGNALING PROTEIN / Ras / SOS / ONCOPROTEIN-DNA Binding Protein complex / ONCOPROTEIN / Protein-protein complex / MAPK / Protein-protein interaction |