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Structure paper

TitleStructure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease.
Journal, issue, pagesEur J Med Chem, Vol. 143, Page 881-890, Year 2017
Publish dateJul 10, 2017 (structure data deposition date)
AuthorsDamalanka, V.C. / Kim, Y. / Galasiti Kankanamalage, A.C. / Rathnayake, A.D. / Mehzabeen, N. / Battaile, K.P. / Lovell, S. / Nguyen, H.N. / Lushington, G.H. / Chang, K.O. / Groutas, W.C.
External linksEur J Med Chem / PubMed:29227928
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-5wej:
1.95 A resolution structure of Norovirus 3CL protease in complex with a dipeptidyl oxazolidinone-based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-V45:
(2S)-2-{(5S)-5-[(3-chlorophenyl)methyl]-2-oxo-1,3-oxazolidin-3-yl}-4-methyl-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}pentanamide

ChemComp-HOH:
WATER

Source
  • norwalk virus
KeywordsHYDROLASE/HYDROLASE inhibitor / PROTEASE / NOROVIRUS / NORWALK VIRUS / ANTIVIRAL INHIBITORS / Oxazolidinone-based DIPEPTIDYL INHIBITOR / HYDROLASE-HYDROLASE inhibitor complex

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