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-Structure paper
Title | An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein. |
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Journal, issue, pages | J. Biol. Chem., Vol. 293, Page 47-68, Year 2018 |
Publish date | Jul 5, 2017 (structure data deposition date) |
Authors | Glidden, M.D. / Aldabbagh, K. / Phillips, N.B. / Carr, K. / Chen, Y.S. / Whittaker, J. / Phillips, M. / Wickramasinghe, N.P. / Rege, N. / Swain, M. ...Glidden, M.D. / Aldabbagh, K. / Phillips, N.B. / Carr, K. / Chen, Y.S. / Whittaker, J. / Phillips, M. / Wickramasinghe, N.P. / Rege, N. / Swain, M. / Peng, Y. / Yang, Y. / Lawrence, M.C. / Yee, V.C. / Ismail-Beigi, F. / Weiss, M.A. |
External links | J. Biol. Chem. / PubMed:29114035 |
Methods | X-ray diffraction |
Resolution | 2.803 Å |
Structure data | PDB-5wdm: |
Source |
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Keywords | HORMONE / single chain / hexamer / designed insulin |