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-Structure paper
Title | Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6). |
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Journal, issue, pages | Eur J Med Chem, Vol. 138, Page 661-668, Year 2017 |
Publish date | Dec 9, 2016 (structure data deposition date) |
Authors | Cingolani, G. / Panella, A. / Perrone, M.G. / Vitale, P. / Di Mauro, G. / Fortuna, C.G. / Armen, R.S. / Ferorelli, S. / Smith, W.L. / Scilimati, A. |
External links | Eur J Med Chem / PubMed:28710965 |
Methods | X-ray diffraction |
Resolution | 2.75 - 2.93 Å |
Structure data | PDB-5u6x: PDB-5wbe: |
Chemicals | ChemComp-HEM: ChemComp-P6A: ChemComp-BOG: ChemComp-63X: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE / COX-1 / CYCLOOXYGENASE / PEROXIDASE / PROSTAGLANDIN / HEME / P6 / oxidoreductase/oxidoreductase inhibitor / MOFEZOLAC / oxidoreductase-oxidoreductase inhibitor complex |