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TitleIdentification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses.
Journal, issue, pagesCell, Vol. 173, Page 1783-1795.e14, Year 2018
Publish dateJun 28, 2017 (structure data deposition date)
AuthorsSajadi, M.M. / Dashti, A. / Rikhtegaran Tehrani, Z. / Tolbert, W.D. / Seaman, M.S. / Ouyang, X. / Gohain, N. / Pazgier, M. / Kim, D. / Cavet, G. ...Sajadi, M.M. / Dashti, A. / Rikhtegaran Tehrani, Z. / Tolbert, W.D. / Seaman, M.S. / Ouyang, X. / Gohain, N. / Pazgier, M. / Kim, D. / Cavet, G. / Yared, J. / Redfield, R.R. / Lewis, G.K. / DeVico, A.L.
External linksCell / PubMed:29731169
MethodsX-ray diffraction
Resolution2.4 - 2.7 Å
Structure data

PDB-5wb9:
Crystal structure of CD4 binding site antibody N60P23 in complex with HIV-1 clade A/E strain 93TH057 gp120 core
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6bck:
Crystal Structure of Broadly Neutralizing Antibody N49P7 in Complex with HIV-1 Clade AE strain 93TH057 gp120 core.
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-MPO:
3[N-MORPHOLINO]PROPANE SULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / CD4 binding site / gp120 core / VIRAL PROTEIN/IMMUNE SYSTEM / HIV-1 / VRC01-CLASS ANTIBODY / CLADE A/E 93TH057 gp120 / viral protein-immune system complex / N49P7 / IMMUNE SYSTEM

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