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-Structure paper
| Title | Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model. |
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| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 27, Page 4370-4376, Year 2017 |
| Publish date | Jun 26, 2017 (structure data deposition date) |
 Authors | Liang, J. / Van Abbema, A. / Balazs, M. / Barrett, K. / Berezhkovsky, L. / Blair, W.S. / Chang, C. / Delarosa, D. / DeVoss, J. / Driscoll, J. ...Liang, J. / Van Abbema, A. / Balazs, M. / Barrett, K. / Berezhkovsky, L. / Blair, W.S. / Chang, C. / Delarosa, D. / DeVoss, J. / Driscoll, J. / Eigenbrot, C. / Goodacre, S. / Ghilardi, N. / MacLeod, C. / Johnson, A. / Bir Kohli, P. / Lai, Y. / Lin, Z. / Mantik, P. / Menghrajani, K. / Nguyen, H. / Peng, I. / Sambrone, A. / Shia, S. / Smith, J. / Sohn, S. / Tsui, V. / Ultsch, M. / Williams, K. / Wu, L.C. / Yang, W. / Zhang, B. / Magnuson, S. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:28830649 |
| Methods | X-ray diffraction |
| Resolution | 1.854 - 2.45 Å |
| Structure data |  PDB-5wal:  PDB-5wev: |
| Chemicals |  ChemComp-9ZS:  ChemComp-HOH: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Tyk2 / Kinase / Inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex / Jak2 |
homo sapiens (human)