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-Structure paper
Title | Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. U.S.A., Vol. 115, Page E886-E895, Year 2018 |
Publish date | Jun 21, 2017 (structure data deposition date) |
Authors | Rezaei Araghi, R. / Bird, G.H. / Ryan, J.A. / Jenson, J.M. / Godes, M. / Pritz, J.R. / Grant, R.A. / Letai, A. / Walensky, L.D. / Keating, A.E. |
External links | Proc. Natl. Acad. Sci. U.S.A. / PubMed:29339518 |
Methods | X-ray diffraction |
Resolution | 1.42 - 1.85 Å |
Structure data | PDB-5w89: PDB-5w8f: |
Chemicals | ChemComp-ZN: ChemComp-HOH: |
Source |
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Keywords | PEPTIDE BINDING PROTEIN / Stapled peptide / BCL-2 family / BH3 domain / apoptosis |