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-Structure paper
Title | Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 27, Page 4908-4913, Year 2017 |
Publish date | Jun 21, 2017 (structure data deposition date) |
Authors | Bhide, R.S. / Keon, A. / Weigelt, C. / Sack, J.S. / Schmidt, R.J. / Lin, S. / Xiao, H.Y. / Spergel, S.H. / Kempson, J. / Pitts, W.J. ...Bhide, R.S. / Keon, A. / Weigelt, C. / Sack, J.S. / Schmidt, R.J. / Lin, S. / Xiao, H.Y. / Spergel, S.H. / Kempson, J. / Pitts, W.J. / Carman, J. / Poss, M.A. |
External links | Bioorg. Med. Chem. Lett. / PubMed:28947151 |
Methods | X-ray diffraction |
Resolution | 2.25 - 2.9 Å |
Structure data | PDB-5w84: PDB-5w85: PDB-5w86: |
Chemicals | ChemComp-9YY: ChemComp-HOH: ChemComp-9YS: ChemComp-9YV: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / SERINE/THREONINE PROTEIN KINASE / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX |