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TitleDiscovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.
Journal, issue, pagesJ. Med. Chem., Vol. 61, Page 4635-4640, Year 2018
Publish dateJun 16, 2017 (structure data deposition date)
AuthorsHumphrey, J.M. / Movsesian, M. / Am Ende, C.W. / Becker, S.L. / Chappie, T.A. / Jenkinson, S. / Liras, J.L. / Liras, S. / Orozco, C. / Pandit, J. ...Humphrey, J.M. / Movsesian, M. / Am Ende, C.W. / Becker, S.L. / Chappie, T.A. / Jenkinson, S. / Liras, J.L. / Liras, S. / Orozco, C. / Pandit, J. / Vajdos, F.F. / Vandeput, F. / Yang, E. / Menniti, F.S.
External linksJ. Med. Chem. / PubMed:29718668
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-5w6e:
PDE1b complexed with compound 3S
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-0NY:
7,8-dimethoxy-N-[(2S)-1-(3-methyl-1H-pyrazol-5-yl)propan-2-yl]quinazolin-4-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHydrolase/Hydrolase Inhibitor / Phosphodiesterase / inhibitor / Hydrolase-Hydrolase Inhibitor complex

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